About the Lab

The du Lac laboratory studies systems and cellular mechanisms of signaling and plasticity in cerebellar and brainstem circuits responsible for balance and eye movements. Experimental strategies taking advantage of mouse molecular genetic tools include quantitative behavioral analyses, optogenetic manipulation of specific neuronal populations, in vivo and in vitro electrophysiology, circuit tracing, and single cell gene expression profiling. Research into fundamental mechanisms of function, dysfunction, and plasticity in brainstem and cerebellar microcircuits aims to provide a foundation for improving clinical treatments of dizziness, balance disorders, and nystagmus..

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Gene ExpressionSingle Cell Gene Expression Profiling

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OptogeneticOptogenetics

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in vitro Electrophysiology in vitro Electrophysiology/span>

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Lab Members

The wonderful lab members of the du Lac Lab

Publications

Publications done by the du Lac Lab
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Selected Publications

Kodama, T. Guerrero, S., Shin, M. Moghadam, S, Faulstich, M. and du Lac, S. Neuronal classification and marker gene identification via single-cell expression profiling of brainstem vestibular neurons subserving cerebellar learning. J. Neurosci. 32: 7819-7831, 2012.

Shin, M., Moghadam, S., Sekirnjak, C., Bagnall, M.W., Kolkman, K.E., Jacobs, R., Faulstich, M. and du Lac, S. Multiple types of cerebellar target neurons and their circuitry in the vestibulo-ocular reflex. J. Neurosci. 31: 10776-10786, 2011.

Kolkman, K.E., McElvain, L.E. and du Lac, S. Diverse precerebellar neurons share similar intrinsic excitability. J. Neurosci. 31: 16665-16674, 2011.

McElvain, L.E., Bagnall, M.W., Sakatos, A., and du Lac, S. Bidirectional plasticity gated by hyperpolarization controls the gain of postsynaptic firing responses at central vestibular nerve synapses. Neuron 68:763-75, 2010.

Gittis, A.H., Moghadam, S.H., and du Lac, S. Mechanisms of sustained high firing rates in two classes of vestibular nucleus neurons: differential contributions of resurgent Na, Kv3, and BK currents. J. Neurophysiol. 104: 1625-34, 2010.

Bagnall, M.B., Zingg, B., Sakatos, A., Moghadam, S.H., Zeilhofer, H.U., and du Lac, S. Glycinergic projection neurons of the cerebellum .J. Neurosci. 29: 10104-10110, 2009.

Bagnall, M.B., McElvain, L.E., Faulstich, M. and du Lac, S. Frequency-independent synaptic transmission supports a linear vestibular behavior. Neuron 60: 343-352, 2008.

Gittis, A.H. and du Lac, S. Firing properties of GABAergic vs non-GABAergic vestibular nucleus neurons conferred by a differential balance of potassium currents. J. Neurophysiol. 97: 3986-3996.

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